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[7] (This interaction is not significant when levodopa is combined with carbidopa, as in standard carbidopa/levodopa therapy, because carbidopa prevents peripheral levodopa breakdown.) Another notable interaction involves the chemotherapeutic agent altretamine: coadministration of pyridoxine can decrease altretamine’s effectiveness and is generally advised against unless specifically directed

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B12 Injections For individuals with severe deficiency or absorption issues, B12 injections may be necessary