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Main pathways of glutamate metabolism in the brain. Glutamate,... | Download Scientific Diagram
The continuous, high-flux conversion of lactate to pyruvate by LDH-B actively lowers the cytosolic NAD + /NADH ratio, leading to a state of reductive stress (that is, a substantially lowered NAD + /NADH ratio)
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This platform is positioned to support either prolonged low-dose suppression or short-course high-dose control in advanced lesions [211]
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