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The review also discusses the physicochemical characteristics of PLGA nanoparticles loaded with neuroprotective compounds, their in vitro/in vivo performance in terms of BBB permeability, biocompatibility, dopaminergic neuron preservation, and behavioral improvements in PD models
Nicotinamide N-Methyltransferase Inhibitor
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Among these inhibitors, one mixed-type inhibitor from hydroxypyridinone-l-phenylalanine conjugates named ((S)-(5-(benzyloxy)-1-octyl-4-oxo-1,4-dihydropyridin-2-yl) methyl 2-amino-3-phenylpropanoate) showed potent inhibitory effect with IC 50 values of 12.6 and 4.0 µM for monophenolase and diphenolase activities, respectively 362
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