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Our results revealed that at 32 μg/mL, LQA_78 led to depletion of intracellular GSH concentration (Figure C) and reduced activity of the superoxide-dismutase enzyme (Figure E), which could explain the ROS accumulation detected in C
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In contrast, elderly patients, facing challenges such as immune senescence and comorbidities, would require lower doses of CAR T cells and strict monitoring for adverse effects to enhance safety (181, 182)
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