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Summary. Depletion of glutathione (GSH) and increased ROS production... | Download Scientific Diagram

The classic structure of the NLRP3 inflammasome (NOD-Like Receptor Protein 3 Inflammasome) comprises three parts: a central nucleotide-binding oligomerization domain (referred to as NACHT), a C-terminal leucine-rich repeat (LRR) domain, and an N-terminal effector domain (the pyrin domain, or PYD), which interacts with downstream signaling molecules to promote pyroptosis

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Anti-tumor immune cells, such as T cells, can induce tumor cells to undergo pyroptosis while simultaneously increasing ROS to trigger ferroptosis, thereby exerting anti-tumor effects (198, 199)

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