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Long-Term Homeostasis of Extracellular Glutamate in the Rat Cerebral Cortex across Sleep and Waking States | Journal of Neuroscience

So when the barrier becomes more permeable, the proposed mechanism is straightforward: substances that should stay in the gut lumen — bacterial fragments, undigested food particles, pathogens — cross into deeper tissue and the bloodstream, where they can drive immune activation and an increased antigenic and toxic load

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Therefore, a deeper understanding of the molecular consequences of drug exposure during brain development should aid in our interpretation of how prior drug experience impacts later-life vulnerability to addiction