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For instance, LPS-induced microglial overactivation triggers the release of NO, TNF-α, IL-1β, and IL-6, leading to neuronal apoptosis and CNS damage (Schnorr et al., 2024)
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Therefore, glutamate is an important signal that mediates the interaction between central neurons and astrocytes, and its normal release and transport are the result of the functional cooperation between neurons and astrocytes
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