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However, the anti-tumor activities of IFN-I have also been well-documented, as studies have demonstrated that IFN-I exert their anticancer effects by negatively regulating the formation of premetastatic niches within the TME [241]
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The incidence of these events increased with high doses and in those human patients that received long-term (more than 90 days) non-steroidal anti-inflammatory drugs (NSAIDs) concomitantly with an anti-NGF monoclonal antibody
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